Yes, the Hyper M.2 x16 Gen 4 card is compatible with the ASUS X670E-E ROG Strix.
Yes, the Hyper M.2 x16 Gen 4 card is compatible with the ASUS X670E-E ROG Strix.
The hyper card should function properly with the ASUS X670E-E ROG Strix motherboard.
Review their frequently asked questions page: https://www.asus.com/support/faq/1037507/