Yes, a heavily modded Fallout 3 can trigger BSOD issues.
Yes, a heavily modded Fallout 3 can trigger BSOD issues.
Checking if 50-60+ mods in Fallout 3 trigger a BSOD or cause a crash is a common concern.
Various factors can lead to a BSOD in games. I've experienced Minecraft crashes due to shader packs. Generally, the game stops working but adding mods increases instability risk. When you see a blue screen, check which mod is causing the issue and remove it—it should resolve the problem.
I doubt there's a "magic number" of mods that will crash the game. But if there's an error, improper installation, incompatibility, or corrupted file somewhere, absolutely. When you're using 50-60 mods, there's a lot of chances for that stuff to happen.
The mods don't cause crashes when using an overclocked GPU or CPU. Running a game or benchmark on such hardware works fine, which helps determine if your overclock is stable.