I got this specific board (Rev 1.0) with a Ryzen 5600 over 2 years ago, and it supported it out of the box. If you're ordering online, it's possible you could get a really old version I suppose, but I suspect you'd be okay. However, If you're buying at retail (or online with accurate pictures) I'm quite sure my box did state right on the front that it was "5000 series ready". Edit: Pic added. Yep, looks like it should say it in bottom left corner