No, a GTX 1080TI is not designed to handle 3x1440p displays.
No, a GTX 1080TI is not designed to handle 3x1440p displays.
Planning to buy three 1440p screens (VG27AQ) with two at 165Hz and one at 144Hz? That sounds doable on your GPU, but you should check if it can handle the load.
Yes, unless you're playing multiple games simultaneously, it's acceptable.