Yes, you can run NBA 2K16 on medium settings.
Hardware details: Intel Celeron J1800, 4 GB RAM, DDR3 R7, 240 MHz, 2 GB DDR3
No, those components aren't capable of handling the task.
It might actually be a problem with the CPU.
The card could work as well, possibly with a modest CPU performance.
You're in for a rough day.