Sure, your RX 580 should work with an DDR3 Intel H61 motherboard.
Sure, your RX 580 should work with an DDR3 Intel H61 motherboard.
Your configuration includes 16 GB RAM, a 600W power supply, an Intel i5-2400 processor.
It should function properly. Many users upgrade from 2000 series CPUs to RX 580 models. Ensure your power supply includes the right cables for the new card—specifically, an 8-pin (6+2) PCIe cable if required. Otherwise, you may need an adapter. Cards from earlier generations might not fit older boards; issues are rare today except on very old systems like Pentium 4 or Athlon models.